A native of Salem, Ohio, Woodruff obtained undergraduate degrees in physical education and teaching and received a master’s degree in education from Columbia University before beginning her career at Oregon in 1929. She started as an assistant professor and transitioned into tenured professor status. As a professor she played an influential role in molding female physical education students for their careers as educators and coaches. Woodruff’s primary responsibilities at Oregon were to coordinate the service course programs, such as swimming and badminton. She was the head of the Teacher Preparation Program for Women during the 1930s and 1940s. She was also the director of the Service Course Program for Women throughout her career.

A field hockey player herself, Woodruff stepped in as the head coach of the women’s field hockey team during her first year on campus and held the post until her retirement in 1967. Although she encouraged athletic interest among women, Woodruff was against excessive competition, as she feared it would hinder the essence of the experience for women. Always known for her professionalism, Woodruff always dressed in wool suits and heels, only “dressing down” for practices.